Ma. Bagum et al., The contribution of low affinity NGF receptor (p75(NGFR)) to delayed neuronal death after ischemia in the gerbil hippocampus, ACT MED OKA, 55(1), 2001, pp. 19-24
The implication of low affinity nerve growth factor receptor (p75(NGFR)), w
hich is believed to play a pro-apoptotic role, in delayed neuronal death (D
ND) after ischemia in the gerbil hippocampus was investigated. Immunohistoc
hemistry and Western blot analysis revealed that the presence of p75 NGFR i
mmunoreactivity (IR) was negligible in the hippocampus of the sham control
gerbil but appeared clearly in CA1 neurons 3 and 4 days after Fi-min transi
ent ischemia, Terminal deoxynucleotidyl transferase-mediated UTP nick end l
abeling (TUNEL) positive nuclei appeared when the level of P75(NGFR) IR inc
reased. Furthermore, almost all TUNEL-positive CA1 neurons also co-stained
for P75(NGFR). These results suggest that p75(NGFR) contributes to DND afte
r ischemia by an apoptotic mechanism.