Effect of different single-bottle dentin adhesives on vascular responses in rat carotid artery

Purpose: To investigate the effect of one-bottle dentin bonding systems on pulpal hemorrhage control in direct pulp exposures through contraction of p ulp blood vessels using the rat carotid artery model. Materials and Methods : Four dentin bonding agents (Prime & Bond 2.1, Prime & Bond NT, Syntac Sin gle Component and Single Bond) were used. The efficacy of bonding agents we re compared to that of epinephrine (control) in the viewpoint of the concen tration applied and the contraction forces induced on the smooth muscle wer e recorded using a force displacement transducer. Results: Three of the tes t materials produced epinephrine-like contractions on the rat carotid arter y (smooth muscle) while no reading could be achieved with Single Bond. A ra nking between the bonding agents for contraction forces was obtained as fol lows: Prime & Bond NT > Prime & Bond 2.1 > Syntac Single Component (P < 0.0 5).