Heterotaxia as an outcome of maternal diabetes: An epidemiological study

There are very few publications on the possible relationship between matern al diabetes and infants presenting heterotaxiaasymmetry defects. In mice, t here is a relationship between maternal diabetes and heterotaxia, although this is influenced by the fetal genotype, An epidemiological analysis of he terotaxia-asymmetry in children born to diabetic mothers (diabetes mellitus or gestational diabetes) is presented here, The analysis is based in the c ase-control study of the ECEMC database. However, due to the very small sam ple size for each type of study of heterotaxia-asymmetry alterations, up to 10 control infants for each case were selected. Although the sample size i s small, the results suggest that only maternal diabetes mellitus significa ntly increases the risk for transposition of great vessels (OR=61.87; CI:7. 36-519.82), and transposition of viscera (OR=24.82; CI;1.84-335.44). (C) 20 01 Wiley-Liss, Inc.