Frosted branch angiitis in a child with HIV infection

PURPOSE: In adults with human immunodeficiency virus (HIV) infection, frost ed branch angiitis is commonly associated with cytomegalovirus retinitis an d responds to anti-cytomegalovirus therapy. We describe the first pediatric case of HIV-associated frosted branch angiitis. METHODS: Case report. RESULTS: A 7-year-old HIV-infected male with frosted branch angiitis was re fractory to induction doses of intravenous ganciclovir and foscarnet over a 2-month period. Although cytomegalovirus antigenemia resolved, the angiiti s only improved after subsequent treatment with systemic corticosteroids, CONCLUSION: Frosted branch angiitis in this patient was not attributed to c ytomegalovirus. The pathogenesis of HIV-associated frosted branch angiitis may differ between children and adults. (Am J Ophthalmol 2001; 131:394-396, (C) 2001 by Elsevier Science Inc. All rights reserved.).