Background: Every year, millions of patients receive sedatives for reductio
n of anxiety before surgery, but there is little objective data on the effe
ct of this treatment on postoperative outcomes, To address this issue, the
effects of benzodiazepine administration were evaluated hi women undergoing
abdominal surgery.
Methods: Patients were randomized to receive 1 mg of oral lorazepam the nig
ht before surgery and 5 mg of intramuscular midazolam on the morning of sur
gery (n = 34), or to receive a placebo the night before surgery and on the
morning of surgery (n = 36). Postoperative pain (Visual Analogue Scale for
pain, McGill Pain Questionnaire) and analgesic consumption (patient-control
led analgesia), and clinical recovery parameters such as time to discharge
from hospital mere evaluated after surgery.
Results: Patient-controlled analgesia use showed a marginal main effect of
treatment group (F(1,51) = 2.8; P = 0.047). Post hoc analysis demonstrated
that patient-controlled analgesia consumption was significantly lower in th
e treatment group only during the first 4 h of patient-controlled analgesia
use after surgery (P = 0.027). There were no significant group differences
at any later postoperative time points (P = not significant). There were n
o group differences in the cumulative Percocet (Pfizer, New York, NY) consu
mption in the postoperative period (P = not significant), Further, self-rep
orted postoperative pain did not differ significantly between groups at any
of the time points (P = not significant). There were also no group differe
nces with regard to any postoperative clinical recovery parameters.
Conclusions: Benzodiazepines administered before surgery have minimal benef
icial effects on the postoperative clinical course of women undergoing abdo
minal hysterectomy.