Liver transplantation from living related donors was unthinkable until rece
ntly, when the safety of modern hepatic surgery became widely appreciated.
The first step was the successful demonstration that parts of livers could
be transplanted. This technique, termed reduced-size liver transplantation,
evolved into reliable procedures to allow parents to donate small parts of
their livers to small children. More recently, right hepatectomy, in which
up to 70% of the Liver is resected for donation, has been performed in adu
lts. As the demand for liver transplantation continues to increase, the dev
elopment of ethically sound, medically and surgically optimal programs for
routine use of living donors has become essential. This chapter provides a
broad overview of the evolution and current state of liver transplantation
with living donors.