Association of MHC and rheumatoid arthritis HLA-DR4 and rheumatoid arthritis: studies in mice and men

Authors
Fugger, L Svejgaard, A
Citation
L. Fugger et A. Svejgaard, Association of MHC and rheumatoid arthritis HLA-DR4 and rheumatoid arthritis: studies in mice and men, ARTHRITIS R, 2(3), 2000, pp. 208-NIL_1
Citations number
29
Categorie Soggetti
Rheumatology
Journal title
ARTHRITIS RESEARCH
ISSN journal
14659913 → ACNP
Volume
2
Issue
3
Year of publication
2000
Pages
208 - NIL_1
Database
ISI
SICI code
1465-9913(2000)2:3<208:AOMARA>2.0.ZU;2-1
Abstract
Inherited susceptibility to rheumatoid arthritis (RA) is asociated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 mole cules. Transgenic mice expressing these major histocompatibility complex (M HC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed.