Synthesis, antiretroviral and antioxidant evaluation of a series of new benzo[b]furan derivatives

Citation
A. Varvaresou et al., Synthesis, antiretroviral and antioxidant evaluation of a series of new benzo[b]furan derivatives, ARZNEI-FOR, 51(2), 2001, pp. 156-162
Citations number
18
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172 → ACNP
Volume
51
Issue
2
Year of publication
2001
Pages
156 - 162
Database
ISI
SICI code
0004-4172(2001)51:2<156:SAAAEO>2.0.ZU;2-A
Abstract
The antiretroviral and anti-oxidant profile of a series of new C-2 and C-7 substituted benzo[b]furans was explored by employing well established antiv iral and antioxidant protocols. The most potent antioxidant compound tested was analog 7, which bears an OH at C-7 and a benzoyl group at C-2. In the influenza A type H3N2 virus screens analog 8a was almost five-fold more act ive than its counterparts and equipotent to rimantadine and amantadine. In the influenza B screening all of the new compounds tested were at least ten -fold more active than the control drug amantadine. The anti-HIV screening, using acutely infected MT-4 cells, showed that compound 8f (n = 4), was fi fteen-fold more active than its monomer congeners, 8a and 8c, d and almost five-fold more potent than monomer 8b and dimer 8f (n = 3).