Lactate dehydrogenase activity and insulin and lactate levels at an altitude below sea level (-350 m) compared to those at an altitude above sea level (620 m) after exercise

This study was designed to investigate the effect of exercise at 350 m belo w sea level altitude (-350 m) on the serum levels of lactate dehydrogenase (LDH), insulin, and lactate. The study was carried out on ten trained adult males with mean age of 23.3 +/- 3.4 years following a 21-km noncompetitive run. Venous blood was withdrawn from the subjects before exercise and 5 mi n post exercise. For comparison purposes, a similar study was performed wit h the same subjects but at 620 m above sea level (+620 m). The results show a significant increase in LDH and lactate levels after exercise only at lo w altitude (-350 m). Serum insulin levels decreased significantly after exe rcise at both altitudes. These changes in serum levels of LDH, insulin, and lactate at different attitudes suggest that a type of metabolic adjustment is present that meets energy requirements during exercise.