Anti-androgenic activity of Myricae Cortex - Isolation of active constituents from bark of Myrica rubra

Authors
Matsuda, H Yamazaki, M Matsuo, K Asanuma, Y Kubo, M
Citation
H. Matsuda et al., Anti-androgenic activity of Myricae Cortex - Isolation of active constituents from bark of Myrica rubra, BIOL PHAR B, 24(3), 2001, pp. 259-263
Citations number
12
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
09186158 → ACNP
Volume
24
Issue
3
Year of publication
2001
Pages
259 - 263
Database
ISI
SICI code
0918-6158(200103)24:3<259:AAOMC->2.0.ZU;2-1
Abstract
The aqueous ethanol extract of Myricae Cortex (bark of Myrica rubra SIEB, e t Zucc., Myrieaceae) showed in vitro testosterone 5 alpha -reductase inhibi tory activity and in vivo anti-androgenic activity using growth of flank or gan in castrated Syrian hamsters and/or hair regrowth after shaving in test osterone-treated C57Black/6CrSlc mice. Three constituents, myricanone, myri canol, and myricetin were identified as the main active principles.