S. Kawamoto et al., Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis, BIOS BIOT B, 65(2), 2001, pp. 431-434
Although clinical evidence has suggested that dysoregulated fatty acid meta
bolism is associated with atopic disorders, the molecular basis for such a
correlation remains to be demonstrated. In the present study, Ne analyzed t
he fatty acid composition in peripheral blood cells of NC/Nga mice, a model
for atopic dermatitis (AD). We found that arachidonic acid significantly a
ccumulated in mice with the AD manifestation. In addition, the leucotriene
B-4-releasing ability upon calcium ionophore A23187 stimulation was potenti
ated in blood cells. An arachidonic acid accumulation was not apparent in t
he non-atopic BALB/c strain, but was still observed in healthy NC/Nga mice
fed under specific pathogen-free conditions. These results indicate that a
disturbed fatty acid metabolism in NC/Nga mice was not a trigger factor for
their dermatitis development.