An in vitro approach to the evaluation of the cross talk between intestinal epithelium and macrophages

Authors
Kanzato, H Manabe, M Shimizu, M
Citation
H. Kanzato et al., An in vitro approach to the evaluation of the cross talk between intestinal epithelium and macrophages, BIOS BIOT B, 65(2), 2001, pp. 449-451
Citations number
7
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
09168451 → ACNP
Volume
65
Issue
2
Year of publication
2001
Pages
449 - 451
Database
ISI
SICI code
0916-8451(200102)65:2<449:AIVATT>2.0.ZU;2-6
Abstract
The intestinal epithelium acts as a mucosal barrier by varying their signal s to immune cells within the intestine. To observe the cross talk between i ntestinal epithelium and macrophages, we establish a Caco-2-THP-1 co-cultur e system. Using this co-culture system, we suggested that paracrine factors of intestinal epithelium increased the phagocytic capacity of intestinal m onocytes /macrophages to be ready for immune and inflammatory responses.