THE POTENTIAL OF COMBINATORIAL PEPTIDE LIBRARIES FOR THE IDENTIFICATION OF INHIBITORS OF TNF-ALPHA MEDIATED CYTOTOXICITY IN-VITRO

The use of random peptide libraries has recently received considerable attention as a new tool for identifying novel therapeutic molecules. The libraries represent an enormous number of peptide sequences displa yed either on the virion surface of filamentous a solid phase syntheti c support. In this minireview we summarize our recent findings on the use of combinatorial peptide libraries to identify antagonists of the biological activities of TNF-alpha, a cytokine which plays a key role in immune and inflammatory responses. (C) 1997 Elsevier Science B.V.