Polymorphic repeat in AIB1 does not alter breast cancer risk

Authors
Haiman, CA Hankinson, SE Spiegelman, D Colditz, GA Willett, WC Speizer, FE Brown, M Hunter, DJ
Citation
Ca. Haiman et al., Polymorphic repeat in AIB1 does not alter breast cancer risk, BREAST CA R, 2(5), 2000, pp. 378-385
Citations number
23
Categorie Soggetti
Oncology
Journal title
BREAST CANCER RESEARCH
ISSN journal
1465542X → ACNP
Volume
2
Issue
5
Year of publication
2000
Pages
378 - 385
Database
ISI
SICI code
1465-542X(2000)2:5<378:PRIADN>2.0.ZU;2-8
Abstract
We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) n ested within the Nurses' Health Study cohort. We observed no association be tween AIB1 genotype and breast cancer incidence, or specific tumor characte ristics. These findings suggest that AIB1 repeat genotype does not influenc e postmenopausal breast cancer risk among Caucasian women in the general po pulation.