Pulsus alternans, alternating weak and strong beats occurring in a heart be
ating at a constant race, has most often been reported in patients with sev
ere, end-stage heart failure. This patient with New York Heart Association
functional class I heart failure developed pulsus alternans during the inot
ropic stimulation of dobutamine that subsequently resolved in a time course
consistent with dobutamine clearance. Thus, in the setting of mildly impai
red myocardial contractility, the inotropic stimulus of dobutamine may prec
ipitate the development of reversible pulsus alternans.