The structure of the carbohydrate backbone of the core-lipid A region of the lipopolysaccharide from Proteus penneri strain 40: new Proteus strains containing open-chain acetal-linked N-acetylgalactosamine in the core part of the LPS

Analysis of the core part of the LPS from several strains of Proteus reveal ed that P. penneri strains 2, 11, 19, 107, and P. vulgaris serotypes O4 and O8 have the same structure with a new type of linkage between monosacchari des an open-chain acetal - that was previously determined for P. vulgaris O X2 and P. penneri 17. The LPS from P. penneri strain 40 contains the same s tructure substituted with one additional monosaccharide: [GRAPHICS] P. vulgaris OX2, O4, O8, P, penneri 2, 11, 17, 19, 107: R = beta -Gal-(1--> or H P. penneri 40 R = alpha -Glc-(1-->6)-Gal-(1 --> where (1S)-GalaNAc(1) is a residue of N-acetyl-D-galactosamine in the open- chain form. It is connected as a cyclic acetal to positions 4 and 6 of the galactosamine residue having a free amino group. All other sugars are in th e pyranose form. (C) 2001 Elsevier Science Ltd. All rights reserved.