Histamine - Can it cause an acute coronary event?

Myocardial infarction (MI) occurring during the course of an allergic urtic arial reaction in the absence of systemic hypotension has been rarely repor ted. This paper reports the case of a 28-year-old woman with no significant risk factors for coronary artery disease who presented with generalized ur ticaria associated with chest pain and had electrocardiographic and enzymat ic evidence of an acute MI. Review of the literature suggests that local hi stamine release may induce spasm of the coronary vasculature, thus leading to myocardial ischemia and infarction.