Rare side-effects of fenofibrate

Citation
R. Rabasa-lhoret et al., Rare side-effects of fenofibrate, DIABETE MET, 27(1), 2001, pp. 66-68
Citations number
18
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
DIABETES & METABOLISM
ISSN journal
12623636 → ACNP
Volume
27
Issue
1
Year of publication
2001
Pages
66 - 68
Database
ISI
SICI code
1262-3636(200102)27:1<66:RSOF>2.0.ZU;2-O
Abstract
Fibrates are widely prescribed as hypolipidemic drugs and are considered as safe. We report the case of a 69 year-old woman who probably developed a m ajor allergic reaction following a Fenofibrate prescription (generic form) of 300 mg per day. Clinical features included asthenia, hyperthermia (40.5 degreesC) and slight muscular pain. Biological abnormalities were mildly el evated muscular enzymes and pancytopenia rapidly developed. All bacteriolog ic, virologic, immune and radiologic investigations were normal. Evolution was spontaneously favorable with Fenofibrate withdrawal. This is the first reported case of major fever and pancytopenia following a Fenofibrate presc ription. Adverse effects of Fenofibrate are briefly reviewed and their usua l favorable outcomes following drug removal are outlined.