Effectiveness of platelet releasate for the treatment at diabetic neuropathic foot ulcers

OBJECTIVE - The goal of this study was to specifically estimate the effecti veness of platelet releasate, a widely available treatment administered by a proprietary group of wound care centers (WCCs) for the treatment of diabe tic neuropathic Foot ulceration. RESEARCH DESIGN AND METHODS - Treatment effectiveness was estimated in a re trospective cohort study controlling For treatment selection bias using log istic regression-derived propensity scores. RESULTS - Platlet releasate was more effective than standard care. The rela tive risk for a wound to heal after treatment with platelet releasate compa red with Standard care at a WCC varied from 1.14 (95% CI 1.03-1.27) to 1.59 (1.49-1.70). The effect was greatest in those with the most severe wounds, i.e., large wounds that affect deeper anatomical structures. CONCLUSIONS - Within the limitations of the ability of propensity score ana lysis to control for. selection bias, platelet releasate is more effective than standard therapy. This effect is more pronounced in more severe wounds , Unfortunately,severe wounds have not been evaluated in randomized clinica l trials of new interventions. We encourage the inclusion of these patients in Future trials.