Thehe broad sprectrum protective effect of the non-protein amino acid beta
-aminobutyric acid (BABA) against numerous plant diseases has been well-doc
umented in the literature. Here, we present an overview of BABA-induced pro
tection in various pathosystems. Contriidictory reports concerning the mech
anism of action underlying this type of protection incited us to take advan
tage of Arabidopsis/pathogen interactions as model systems to investigate t
he action of BABA at the genetic and molecular level. We present evidence t
hat the protective effect of BABA is due to a potentiation of natural defen
se mechanisms against biotic and abiotic stresses. In order to dissect the
pathways involved in potentiation by BABA describe the use of a mutational
approach based on BABA-induced female sterility in Arabidopsis.