Manometric heterogeneity in patients with idiopathic achalasia

Citation
I. Hirano et al., Manometric heterogeneity in patients with idiopathic achalasia, GASTROENTY, 120(4), 2001, pp. 789-798
Citations number
19
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
GASTROENTEROLOGY
ISSN journal
00165085 → ACNP
Volume
120
Issue
4
Year of publication
2001
Pages
789 - 798
Database
ISI
SICI code
0016-5085(200103)120:4<789:MHIPWI>2.0.ZU;2-D
Abstract
Background & Aims: In certain cases of achalasia, particularly those in ear ly stages with minimal endoscopic or radiographic abnormalities, the diagno sis may rely on manometry, which is the most sensitive test for the disease . The aim of this study was to critically evaluate the manometric criteria in a population of patient with idiopathic achalasia. Methods: Clinical his tories and manometric recordings of 58 patients with idiopathic achalasia a nd 43 control subjects were analyzed with regard to esophageal body contrac tion amplitude, peristaltic effectiveness in terms of both completeness and propagation velocity, lower esophageal sphincter (LES) resting pressure, L ES relaxation pressure, and intraesophageal-intragastric pressure gradient, Variants of achalasia were defined by finding manometric features that sig nificantly differed from the remainder of achalasia patients, such that the diagnosis might be questioned. Results: Four manometrically distinct varia nts were identified. These variants were characterized by (1) the presence of high amplitude esophageal body contractions, (2) a short segment of esop hageal body aperistalsis, (3) retained complete deglutitive LES relaxation, and (4) intact transient LES relaxation, In each instance, the most extrem e variant is discussed and compared with the remainder of the achalasia pop ulation and with controls. Conclusions: The significance in defining these variants of achalasia lies in the recognition that these sometimes confusin g manometric findings are consistent with achalasia when combined with addi tional clinical data supportive of the diagnosis. Furthermore, such variant s provide important clues into the pathophysiology of this rare disorder.