Synthesis of 1-substituted indole-3-carboxaldehyde related to acyclic nucleosides and their condensed pyrenyl derivatives

Authors
Zahran, MA Afify, HM Pedersen, EB Nielsen, C
Citation
Ma. Zahran et al., Synthesis of 1-substituted indole-3-carboxaldehyde related to acyclic nucleosides and their condensed pyrenyl derivatives, J CHEM R-S, (1), 2001, pp. 9-9
Citations number
9
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF CHEMICAL RESEARCH-S
ISSN journal
03082342 → ACNP
Issue
1
Year of publication
2001
Pages
9 - 9
Database
ISI
SICI code
0308-2342(200101):1<9:SO1IRT>2.0.ZU;2-I
Abstract
Indole-3-carboxaldehyde was N-alkylated to give the corresponding acyclic n ucleosides 3a-h which were condensed with 1-pyrenamine and 1-acetylpyrene t o give 5a,c,e-g and 7b-d,e,g, respectively. The Schiff's bases 5a and 5e wi th 2-hydroxyethyl and methylthiomethyl N-1 substituents were found moderate ly active against HIV-1.