The interaction of tributyllead with lysosomes from rat liver

Authors
Bragadin, M Marton, D Manente, S Toninello, A
Citation
M. Bragadin et al., The interaction of tributyllead with lysosomes from rat liver, J INORG BIO, 83(2-3), 2001, pp. 229-232
Citations number
27
Categorie Soggetti
Biochemistry & Biophysics","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF INORGANIC BIOCHEMISTRY
ISSN journal
01620134 → ACNP
Volume
83
Issue
2-3
Year of publication
2001
Pages
229 - 232
Database
ISI
SICI code
0162-0134(20010115)83:2-3<229:TIOTWL>2.0.ZU;2-A
Abstract
The interactions of tributyllead with lysosomes from rat liver have been st udied. It results that the organometal compound induces a fast alkalinizati on in energized lysosomes. The interpretation is that the compound is a pot ent proton carrier. This function could explain the toxicity, in particular at neurological level of the compound. (C) 2001 Elsevier Science B.V. All rights reserved.