A. Duflos et al., Hydroxylation of yohimbine in superacidic media: One-step access to human metabolites 10 and 11-hydroxyyohimbine, J NAT PROD, 64(2), 2001, pp. 193-195
Two major human metabolites of yohimbine (1), 10- and 11-hydroxyyohimbine (
2 and 3), were prepared by direct hydroxylation of 1 under superacidic cond
itions. In this medium, the four positions of the benzene part of yohimbine
were hydroxylated and the corresponding monohydroxylated compounds (2-5) w
ere isolated. The structures of 2-5 were elucidated by spectroscopic method
s including 1D and 2D NMR techniques.