Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonosporaalba

Authors
Suzuki, K Yahara, S Maehata, K Uyeda, M
Citation
K. Suzuki et al., Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonosporaalba, J NAT PROD, 64(2), 2001, pp. 204-207
Citations number
18
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
2
Year of publication
2001
Pages
204 - 207
Database
ISI
SICI code
0163-3864(200102)64:2<204:IANTIP>2.0.ZU;2-C
Abstract
A novel inhibitor of topoisomerase I designated as isoaurostatin (1) was is olated from the culture filtrate of Thermomonospora alba strain No. 1520. T he structure of 1 was determined to be 6,4'-dihydroxyisoaurone on the basis of spectroscopic (NMR and MS) methods. Compound 1 inhibited the relaxation activity of calf thymus topoisomerase I in a noncompetitive manner and did not inhibit the relaxation and decatenation of human placenta topoisomeras e II. Compound 1 is an inhibitor belonging to cleavable complex-nonforming type without DNA intercalation.