New bioactive sulfated metabolites from the Mediterranean tunicate Sidnyumturbinatum

Authors
Aiello, A Carbonelli, S Fattorusso, E Iuvone, T Menna, M
Citation
A. Aiello et al., New bioactive sulfated metabolites from the Mediterranean tunicate Sidnyumturbinatum, J NAT PROD, 64(2), 2001, pp. 219-221
Citations number
6
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
2
Year of publication
2001
Pages
219 - 221
Database
ISI
SICI code
0163-3864(200102)64:2<219:NBSMFT>2.0.ZU;2-3
Abstract
In addition to the known sodium 3,7,11,15-tetramethylhexadeca-1,19-diyl sul fate (4), the BuOH extract of the Mediterranean tunicate Sidnyum turbinatum was shown to contain four new metabolites: 1-heptadecanyl sulfate (1), 1-o ctadecanyl sulfate (2), sodium (2S)-2,6,10,14-tetramethylpentadeca-1,18- di yl sulfate (3), and 1-hexyl sulfate (5). Their structures were determined b y spectroscopic and chemical methods. Compounds 1-5 exhibited in vitro anti proliferative activity estimated on the WEHI 164 cell line.