Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea

Authors
Ito, A Cui, BL Chavez, D Chai, HB Shin, YG Kawanishi, K Kardono, LBS Riswan, S Farnsworth, NR Cordell, GA Pezzuto, JM Kinghorn, AD
Citation
A. Ito et al., Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea, J NAT PROD, 64(2), 2001, pp. 246-248
Citations number
9
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
2
Year of publication
2001
Pages
246 - 248
Database
ISI
SICI code
0163-3864(200102)64:2<246:CPFTTO>2.0.ZU;2-X
Abstract
Bioassay-guided investigation of the twigs of Ochanostachys amentacea using LNCaP (hormone-dependent human prostate cancer) cells as a monitor led to the isolation of three alkynes, the known (S)-17-hydroxy-9,11,13,15-octadec atetraynoic acid (minquartynoic acid, 1) and two novel analogues, (S)-17,18 -dihydroxy-9,11,13,15-octadecatetraynoic acid (2) and (S)-17-hydroxy-15E-oc tadecen-9,11,13-triynoic acid (3). Compounds 1-3 were tested against a pane l of human tumor cell lines and found to be significantly cytotoxic.