A novel anti-HIV macrocyclic peptide from Palicourea condensata

Authors
Bokesch, HR Pannell, LK Cochran, PK Sowder, RC McKee, TC Boyd, MR
Citation
Hr. Bokesch et al., A novel anti-HIV macrocyclic peptide from Palicourea condensata, J NAT PROD, 64(2), 2001, pp. 249-250
Citations number
16
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
2
Year of publication
2001
Pages
249 - 250
Database
ISI
SICI code
0163-3864(200102)64:2<249:ANAMPF>2.0.ZU;2-L
Abstract
A 37 amino acid cyclic polypeptide has been isolated from the organic extra ct of the tropical tree Palicourea condensata. Palicourein (1) is the large st of a growing family of plant peptides that contain a cyclized amino acid backbone cross-linked via three internal disulfide bridges. Palicourein in hibits the in vitro cytopathic effects of HIV-1(RF) infection of CEM-SS cel ls with an EC50 value of 0.1 muM and an IC50 value of 1.5 muM.