Retinol-binding protein in idiopathic intracranial hypertension (IIH)

Citation
Jb. Selhorst et al., Retinol-binding protein in idiopathic intracranial hypertension (IIH), J NEURO-OPH, 20(4), 2000, pp. 250-252
Citations number
23
Categorie Soggetti
Optalmology
Journal title
JOURNAL OF NEURO-OPHTHALMOLOGY
ISSN journal
10708022 → ACNP
Volume
20
Issue
4
Year of publication
2000
Pages
250 - 252
Database
ISI
SICI code
1070-8022(200012)20:4<250:RPIIIH>2.0.ZU;2-5
Abstract
Objective: We postulated that an alteration in endogenous vitamin A (retino l) metabolism plays a causal role in the pathogenesis of idiopathic intracr anial hypertension (IIH). Materials and Methods: Serum retinol was determined by a fluorometric metho d from 40 control subjects and 58 patients with idiopathic intracranial hyp ertension (IIH). Retinol binding protein (RBP) was also assayed by quantita tive radial immunodiffusion in 17 control subjects and 30 patients with IIH . Results: Mean retinol values were higher in the IIH group compared with the control group, but did not reach a significant level. However, seven of 30 patients with IIH had high REP levels, but none of the control subjects di d. Conclusion: This data suggests that IIH is associated with an abnormality i n vitamin A metabolism that is linked to its transport system.