Biochemical and physiological characteristics of fat cell

Since animals are under constant threat of starvation, storage of energy so urces inside the body is essential for various activities. Therefore, anima ls exhibit highly sophisticated mechanisms for storing energy inside their bodies in adipose tissue. However, in humans it has been clarified that fat cell (adipocyte, which comprises adipose tissues) differentiation and the extent of subsequent fat accumulation (hypertrophy of cells) are closely as sociated with the occurrence and advancement of various diseases resulting from obesity. Moreover, progress in biochemical studies with respect to adi pocyte in recent years has rapidly clarified new functions and differentiat ion mechanisms of adipocytes. Interesting points, in particular, are the fu nction of white adipocytes as "secreting cells" and the molecular mechanism of adipocyte differentiation via the nuclear receptors. Consequently, adip ose tissue is being targeted to prevent or treat many common diseases, This paper summarizes recent knowledge on characteristics, differentiation and proliferation of adipocytes and the mechanisms by which adipocytes are regu lated.