Synthetic studies of a didemnin B analog based on a 2,3-diamino sugar scaffolding

Authors
Ramanjulu, JM Joullie, MM Li, WR
Citation
Jm. Ramanjulu et al., Synthetic studies of a didemnin B analog based on a 2,3-diamino sugar scaffolding, J CHIN CHEM, 48(1), 2001, pp. 1-4
Citations number
9
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
ISSN journal
00094536 → ACNP
Volume
48
Issue
1
Year of publication
2001
Pages
1 - 4
Database
ISI
SICI code
0009-4536(200102)48:1<1:SSOADB>2.0.ZU;2-K
Abstract
Reductive amination, amide formation using BOP [(1H-1,2,3-benzotriazol-1-yl oxy)tris(dimethylamino)-phosphonium hexafluorophosphate] and esterification via DCC (dicyclohexylcarbodiimide) were the key synthetic steps to generat e an advanced intermediate in the preparation of a didemnin B analog based on a sugar scaffolding (2). This analog should provide insight into the bio active conformation of didemnin B.