An estrogen-like activity in pomegranate juice

Authors
Maru, I Ohnishi, J Yamaguchi, S Oda, Y Kakehi, K Ohta, Y
Citation
I. Maru et al., An estrogen-like activity in pomegranate juice, J JPN SOC F, 48(2), 2001, pp. 146-149
Citations number
7
Categorie Soggetti
Food Science/Nutrition
Journal title
JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI
ISSN journal
1341027X → ACNP
Volume
48
Issue
2
Year of publication
2001
Pages
146 - 149
Database
ISI
SICI code
1341-027X(2001)48:2<146:AEAIPJ>2.0.ZU;2-7
Abstract
We examined an estrogen-like activity in the pomegranate (Punica granatum) juice. The juice or its methanol eluate from C18 cartridge competed with 17 beta -estradiol for estrogen receptor (ER) binding and also stimulated pro liferation of human ER-positive cell (MCF-7) in vitro. Furthermore, they ef fectively increased uterine weight in the ovariectomized rat. On the basis of these data, ne concluded that the pomegranate juice contained estrogen-l ike compounds.