Trousseau's syndrome treated with long-term subcutaneous lepirudin (case report and review of the literature)

We report here a case of recurrent venous and arterial thromboembolism, Tro usseau's syndrome, in a cancer patient who developed heparin-induced thromb ocytopenia. She was treated with lepirudin and after establishing the patie nt-specific half-life for subcutaneous lepirudin, she was successfully main tained on this therapy for more than eight months.To our knowledge this cas e represents the longest reported use of subcutaneous lepirudin.