Investigation of biochemical and haematological side-effects of enrofloxacin in dogs

In the present study, effects of enrofloxacin on biochemical, haematologica l and blood gas parameters were investigated. Changes in laboratory paramet ers were monitored during the treatment period. Enrofloxacin was administer ed (5 mg/kg intramuscularly, once daily) to 10 healthy dogs for 14 days. Ac idosis and temporary increases in aspartate aminotransferase, indirect bili rubin, sodium, partial pressure of CO2 and mean corpuscular volume levels a s well as decreased levels of inorganic phosphorus, ionized calcium, potass ium, partial pressure of O-2 and standard bicarbonate were observed. The re sults of this study suggest that these observed effects of enrofloxacin on blood gas parameters should be taken into consideration in long-term use of the drug.