J-IMPEACH-MBC: a new concatenated NMR experiment for F-1 scalable, J-resolved HMBC

A new and improved NMR experiment for F-1 scalable, J-Resolved HMBC is pres ented. This experiment, called J-IMPEACH-MBC, utilizes a minimum number of 180 degrees pulses to preserve maximum signal-to-noise ratio and provides a variable scaling factor (N) that can be used to scale the heteronuclear co uplings in F-1. It should prove to be useful for the determination of relat ive stereochemistry and other structural problems. In addition, a descripti on of the advantages of the J-IMPEACH-MBC compared with the J-Resolved HMBC -2 is presented. The method is exemplified with strychnine. Copyright (C) 2 001 John Wiley & Sons, Ltd.