Phaeohyphomycosis due to Cladosporium cladosporioides

Phaeohyphomycosis is a clinical entity caused by dematiaceous fungi. We des cribe a clinical case of phaeohyphomycosis due to Cladosporium cladosporioi des in a 45-year-old white male, apparently healthy, human immunodeficiency virus-negative. The patient was treated with terbinafine for 9 months, wit h regression of a skin lesion. Three months after discontinuation of the th erapy, there was a clinical and mycological relapse. After progression of t he disease with inadequate treatment, there was no response to amphotericin B and flucytosine. Finally, we obtained a clinical response with itraconaz ole oral solution at 600 mg day(-1) for a 6-month period.