Gynecologic malignancies accompanied by benign hormone-dependent diseases

Objective: To investigate the correlation between benign gynecologic diseas es and hormone-dependent malignancies such as endometrial carcinoma in post menopausal women. Design: We retrospectively analyzed the prevalence of myoma uteri and adeno myosis uteri in 136 cases of endometrial carcinomas. We used 222 uterine pr olapse cases as controls. Results: The results showed that 21.6% and 9.9% of healthy postmenopausal w omen (control) had myoma uteri and adenomyosis uteri, respectively, after t he cessation of menses. However, postmenopausal women with endometrial carc inomas had a 1.5- to 2-fold higher prevalence, respectively, for myoma uter i and adenomyosis uteri as compared with the postmenopausal control women. Conclusion: There was a higher prevalence of myoma uteri and adenomyosis ut eri in postmenopausal patients with endometrial carcinomas than in the cont rol population.