COMMUNICATION BETWEEN THE EXTRACELLULAR ENVIRONMENT, CYTOPLASMIC SIGNALING CASCADES AND THE NUCLEAR CELL-CYCLE MACHINERY

In the past decade, we have gained considerable insight into the ident ities of various cytoplasmic signal transduction cascades and the mann er in which they operate in response to changes in the extracellular e nvironment, Moreover, we have begun to understand what the key players are in cell-cycle regulation and how they, in turn, function to promo te cell division. A long-standing question, however, has been how comm unication between signalling routes and the cell-cycle machinery occur s. This review highlights some recent observations that provide possib le links between signal transduction and the cell-cycle machinery. (C) 1997 Federation of European Biochemical Societies.