LOCAL WOUND AND SYSTEMIC COAGULATION FIBRINOLYSIS RESPONSES IN HIP-ARTHROPLASTY - INFLUENCE OF ALLOGENEIC AND AUTOLOGOUS BLOOD-TRANSFUSION/

22 patients undergoing elective hip arthroplasty were studied. in 12 p atients, a closed-loop autotransfusion system, without anticoagulant, was used and 10 had an ordinary wound drainage allowing repeated blood sampling from the wound. Plasma concentrations of antithrombin (AT), fibrin, soluble (SF) and fibrin D-dimer were determined preoperatively , 3, 8, and 24 hours after starting surgery. Wound drainage blood had increased concentrations of SF and fibrin D-dimer and decreased concen trations of AT compared to reference values and systemic concentration s in patients. Plasma concentrations of SF, fibrin D-dimer and AT did not differ between patients receiving retrieved blood and those receiv ing stored red blood cell concentrates (RBCs). Patients receiving bloo d transfusions had lower AT concentrations at 8 hours after starting s urgery than those not receiving such a transfusion.