New 3 '-deoxythymidines bearing a nucleophilic 3 '-substituent

Authors
Belostotskii, AM Keren-Yeshuah, H Lexner, J Hassner, A
Citation
Am. Belostotskii et al., New 3 '-deoxythymidines bearing a nucleophilic 3 '-substituent, NUCLEOS NUC, 20(1-2), 2001, pp. 93-101
Citations number
32
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
1-2
Year of publication
2001
Pages
93 - 101
Database
ISI
SICI code
1525-7770(2001)20:1-2<93:N3'BAN>2.0.ZU;2-3
Abstract
New potential cancer-driven as well as HIV-driven nucleoside heteroanalogs, such as 3'-thio- and 3'- as well as 5'-selenosubstituted thymidines, have been synthesized. We also report an effective method for the preparation of novel nucleoside derivatives, bis(deoxynucleoside) diselenides, in nearly quantitative yields. The North conformation is significantly populated in t he conformational equilibrium for-3'-alpha -alkylthiothymidines.