DETERMINATION OF BENAZEPRIL AND CILAZAPRIL IN PHARMACEUTICALS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

A high performance liquid chromatography method was developed for the specific determination of new angiotensin-converting enzyme inhibitors benazepril and cilazapril in pharmaceutical dosage forms. The propose d method was conducted using a reverse phase technique, UV monitoring at 211 nn and enalapril as an internal standard. The detector response was linear in the range of 10-50 mu g/mL for benazepril and 40-200 mu g/mL, for cilazapril. The drugs were extracted from tablets with meth anol. The percentage recoveries ranged from 96.34 to 102.04 and from 1 03.08 to 107.96 for benazepril and cilazapril, respectively.