SYNTHESIS OF NEW MORPHINE DERIVATIVES CONTAINING HALOGEN IN THE AROMATIC RING

Authors
HOSZTAFI S MAKLEIT S
Citation
S. Hosztafi et S. Makleit, SYNTHESIS OF NEW MORPHINE DERIVATIVES CONTAINING HALOGEN IN THE AROMATIC RING, Synthetic communications, 24(21), 1994, pp. 3031-3045
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
24
Issue
21
Year of publication
1994
Pages
3031 - 3045
Database
ISI
SICI code
0039-7911(1994)24:21<3031:SONMDC>2.0.ZU;2-B
Abstract
The C-1 halogenated (brominated and chlorinated) analogues of morphine , codeine and their dihydro derivatives have been synthesized by means of known and new procedures. Hitherto unknown N-demethylation of thes e derivatives has also been explored, and several new N-demethyl-N-sub stituted analogues (allyl, n-propyl) have been prepared with the aim o f contributing to a better understanding of certain details of the str ucture-activity relationships of the morphine alkaloids.