Complex formation reactions of (N,N '-dimethylethylenediamine) palladium(II) with various biologically relevant ligands

cis-Dichloro-(N,N'-dimethylethylenediamine)palladium(II) [Pd(Me(2)en)Cl-2] was synthesized and characterized. Stoichiometry and stability constants of the complexes formed between [Pd(Me(2)en)(H2O)(2)](2+) with various biolog ically relevant ligands are investigated. The ligands used are dicarboxylic acids, amino acids, peptides and DNA unit constituents. The results showed the formation of 1:1 complexes with amino acids and dicarboxylic acids. Pe ptides forms both I:1 complexes and the corresponding deprotonated amide sp ecies. DNA constituents form both 1:1 and 1:2 complexes. The concentration distribution of the complexes in solution was evaluated. [Pd(Me(2)en)Cl-2] and [Pd(Me(2)en)(CBDCA)] were isolated and characterized by elemental analy sis, FTIR, H-1 NMR, mass spectra and thermal analysis (TGA). (C) 2001 Elsev ier Science B.V. All rights reserved.