Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

Authors
Saiardi, A Nagata, E Luo, HBR Sawa, A Luo, XJ Snowman, AM Snyder, SH
Citation
A. Saiardi et al., Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate, P NAS US, 98(5), 2001, pp. 2306-2311
Citations number
33
Categorie Soggetti
Multidisciplinary
Journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN journal
00278424 → ACNP
Volume
98
Issue
5
Year of publication
2001
Pages
2306 - 2311
Database
ISI
SICI code
0027-8424(20010227)98:5<2306:MIPMSI>2.0.ZU;2-F
Abstract
Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catal ytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK). By phosphorylating inosit ol 4.5-bisphosphate, mIPMK provides an alternative biosynthesis for inosito l 1,4,5-trisphosphate [Ins(1,4,5)P-3]. mlPMK also can form the pyrophosphat e disphosphoinositol tetrakisphosphate (PP-InsP(4)) from InsP(5). Additiona lly, mIPMK forms InsP(4) from lns(1,4,5)P-3 and InsP(5) from lns(1,3,4,5)P- 4.