OVEREXPRESSION OF CYCLIN D1 AND P53 ASSOCIATED WITH DISEASE RECURRENCE IN COLORECTAL ADENOCARCINOMA

Multiple genetic changes occur during the evolution of normal cells in to cancer cells. It has been reported that both cyclin DI and p53 gene s play major roles in oncogenesis and/or cell cycle control in various cancers. In this study, we examined the overexpression of cyclin DI a nd p53 by the immunohistochemical method and investigated the correlat ion between expression of these antigen and prognosis in patients with colorectal adenocarcinoma. Disease-free survival was significantly lo wer in the patients with cuclin DI-strongly positive tumors than in th ose with cyclin DI-negative tumors. Similarly, disease-free survival o f the patients with p53-strongly positive tumors was significantly low er than that of those with p53-negative tumors. Moreover, multivariate ! analysis indicated that both cyclin DI and p53 overexpression are in dependent prognostic factors in patients with colorectal adenocarcinom a. In conclusion, both cyclin DI and p53 overexpression may be useful predictors of disease recurrence in patients with colorectal adenocarc inoma. (C) 1997 Wiley-Liss, Inc.