New asymmetric synthesis of dexecadotril and ecadotril starting from a single precursor

Authors
Monteil, T Danvy, D Plaquevent, JC Duhamel, L Duhamel, P Gros, C Schwartz, JC Lecomte, JM
Citation
T. Monteil et al., New asymmetric synthesis of dexecadotril and ecadotril starting from a single precursor, SYN COMMUN, 31(2), 2001, pp. 211-218
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
31
Issue
2
Year of publication
2001
Pages
211 - 218
Database
ISI
SICI code
0039-7911(2001)31:2<211:NASODA>2.0.ZU;2-4
Abstract
We describe herein a method providing access to both enantiomers of 3-acety lthio-2-benzylpropionic acid via enzymatic desymmetrization of 2-benzyl-1,3 -propanediol. These compounds are respectively the starting materials for t he synthesis of ecadotril, and dexecadotril, which are powerful inhibitors of NEP (EC 3.4.24.11) and have been developed as therapeutic agents.