An improved synthesis of N-[(9-hydroxymethyl)-2-fluorenyl]succinamic acid (HMFS), a versatile handle for the solid-phase synthesis of biomolecules

Authors
Albericio, F Cruz, M Debethune, L Eritja, R Giralt, E Grandas, A Marchan, V Pastor, JJ Pedroso, E Rabanal, F Royo, M
Citation
F. Albericio et al., An improved synthesis of N-[(9-hydroxymethyl)-2-fluorenyl]succinamic acid (HMFS), a versatile handle for the solid-phase synthesis of biomolecules, SYN COMMUN, 31(2), 2001, pp. 225-232
Citations number
11
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
31
Issue
2
Year of publication
2001
Pages
225 - 232
Database
ISI
SICI code
0039-7911(2001)31:2<225:AISONA>2.0.ZU;2-D
Abstract
The optimization of a synthetic process for the preparation of HMFS handle, which is used for the solid-phase synthesis of peptides and oligonucleotid es, is presented.