Synthesis of 1-arylsulfonyl-3-N-(beta-D-acetylglycopyranos-1-yl)-5-fluorouracil and antitumor activities

Authors
Sun, CJ Zhang, JM Wang, SJ Zhou, FY Qi, YX Lu, M
Citation
Cj. Sun et al., Synthesis of 1-arylsulfonyl-3-N-(beta-D-acetylglycopyranos-1-yl)-5-fluorouracil and antitumor activities, SYN COMMUN, 31(1), 2001, pp. 71-75
Citations number
5
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
31
Issue
1
Year of publication
2001
Pages
71 - 75
Database
ISI
SICI code
0039-7911(2001)31:1<71:SO1>2.0.ZU;2-A
Abstract
Fifteen glycosides of 1-arylsulfonyl-5-fluorouracil were synthesized by the reaction of 1-arylsulfonyl-5-fluorouracil with bromoacetylglucose or bromo acetylxylose under phase transfer catalysis. Their structures were confirme d by IR, (HNMR)-H-1, and elementary analysis. Preliminary results of in vit ro tests showed that some of them have certain antitumor activities.