Synthesis of natural amide alkaloid piperdardine and a new bioactive analogue

Authors
de Araujo-Junior, JX Duarte, CD Chaves, MCD Parente, JP Fraga, CAM Barreiro, EJ
Citation
Jx. De Araujo-junior et al., Synthesis of natural amide alkaloid piperdardine and a new bioactive analogue, SYN COMMUN, 31(1), 2001, pp. 117-123
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
31
Issue
1
Year of publication
2001
Pages
117 - 123
Database
ISI
SICI code
0039-7911(2001)31:1<117:SONAAP>2.0.ZU;2-W
Abstract
Piperdardine, (E,E)-1-[7-(1,3-benzodioxol-5-yl)-1-oxo-2,4-heptadienyl] -pip eridine, isolated from the stem of Piper tuberculatum, was synthesized in 2 1% overall yield by an efficient pathway, in which safrole, an abundant Bra zilian essential oil from Ocotea pretiosa, was used as starting material.