Epidemiology of ischemic heart disease and peculiarities of atherosclerosis in male residents of Yakutsk

Aim. To study trends in prevalence, risk factors (RF) and mortality of isch emic heart disease (IHD), contribution of RF to risk of death due to IHD an d other cardiovascular diseases (CVD) among male population of Yakutsk; to determine characteristics of atherosclerosis among native male population a nd migrants. Material and methods. A clinicopathological epidemiological trial covered m ale population of Yakutsk. It was performed by standard techniques within t he scope of the cooperative program. Results. The analysis of the trends for the last 10 years demonstrates a ma rked rise in the incidence rates of arterial hypertension (AH), overweight and hypercholesterolemia. CVD mortality reached 38.4% of overall mortality. Such factors as AH, smoking, IHD, ischemic ECG changes and overweight cont ribute much to the integral risk of CVD death. A comparative morphometric a nalysis of atherosclerosis development in 1965-1968 and 1985-1988 showed ac celerated development of atherosclerosis both among native population and m igrants in 1985-1988. There are population differences in development of at herosclerosis in males from native population and migrants. The effects of trace elements on formation of atherosclerosis components in the Far North were evaluated. Conclusion. Present-day epidemiological situation in relation to IHD and ot her CVD necessitates further monitoring of the situation, activation of pri mary and secondary IHD prevention among population of the Far North.